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TE/TM biosensors for measuring conformational changes

Research Area: Lab-on-a-chip label-free biosensors

Main Researcher: Jan-Willem Hoste

Traditional ring resonator sensor have the disadvantage that they only measure total mass, and therefore cannot make a distinction between a thin dense layer and an equivalent thick less dense layer. Therefore, they are insensitive to conformational changes (changes in shape) of biomolecules.

By designing the rings such that they support two polarisations, we can perform two measurements which allows us to separately measure refractive index and layer thickness.

This opens up important applications in the fields of drug discovery and fundamental research


Other people involved:

Publications

    International Journals

  1. A. Van Eeghem, S. Werquin, J.F.I.B Hoste, A. Goes, E. Vanderleyden, P. Dubruel, P. Bienstman, Double positive effect of adding hexaethyelene glycol when optimizing the hybridization efficiency of a microring DNA detection assay, Applied Surface Science, p.321-328 (2017)  Download this Publication (1.7MB).
  2. J.W. Hoste, S. Werquin, T. Claes, P. Bienstman, Conformational analysis of proteins with a dual polarisation silicon microring, Optics Express, 22(3), p.2807-2820 (2014)  Download this Publication (11.5MB).

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