TE/TM biosensors for measuring conformational changes
Lab-on-a-chip label-free biosensors
Main Researcher: Jan-Willem Hoste
Traditional ring resonator sensor have the disadvantage that they only measure total mass, and therefore cannot make a distinction between a thin dense layer and an equivalent thick less dense layer. Therefore, they are insensitive to conformational changes (changes in shape) of biomolecules.
By designing the rings such that they support two polarisations, we can perform two measurements which allows us to separately measure refractive index and layer thickness.
This opens up important applications in the fields of drug discovery and fundamental research
Other people involved:
PublicationsBack to overview
A. Van Eeghem, S. Werquin, J.F.I.B Hoste, A. Goes, E. Vanderleyden, P. Dubruel, P. Bienstman,
Double positive effect of adding hexaethyelene glycol when optimizing the hybridization efficiency of a microring DNA detection assay, Applied Surface Science, p.321-328 (2017) .
J.W. Hoste, S. Werquin, T. Claes, P. Bienstman,
Conformational analysis of proteins with a dual polarisation silicon microring, Optics Express, 22(3), p.2807-2820 (2014) .