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Authors: J.F.I.B Hoste, S. Werquin, T. Claes, P. Bienstman
Title: Conformational analysis of proteins with a dual polarisation silicon microring
Format: International Journal
Publication date: 2/2014
Journal/Conference/Book: Optics Express
Editor/Publisher: Andrew M. Weiner, 
Volume(Issue): 22(3) p.2807-2820
DOI: 10.1364/oe.22.002807
Citations: 36 (Dimensions.ai - last update: 5/12/2021)
24 (OpenCitations - last update: 19/4/2021)
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Abstract

Optical microresonator biosensors have proven to be a valid
tool to perform affinity analysis of a biological binding event. However,
when these microresonators are excited with a single optical mode they
can not distinguish between a thin dense layer of biomolecules or a thick
sparse layer. This means the sensor is ”blind” to changes in shape of
bound biomolecules. We succeeded in exciting a Silicon-on-Insulator
(SOI) microring with TE and TM polarisations simultaneously by using
an asymmetrical directional coupler and as such were able to seperately
determine the thickness and the density (or refractive index) of a bound
biolayer. A proof-of-concept is given by determining both parameters of
deposited dielectric layers and by analysing the conformational changes of
Bovine Serum Albumin (BSA) proteins due to a change in pH of the buffer.

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