| Authors: | K. De Vos, I. Bartolozzi, P. Bienstman, R. Baets, E. Schacht | | Title: | Optical Biosensor based on Silicon-on-Insulator Microring Resonators for Specific Protein Binding Detection | | Format: | International Conference Proceedings | | Publication date: | 12/2006 | | Journal/Conference/Book: | LEOS Benelux Annual Symposium
| | Location: | Eindhoven, Netherlands | | Citations: | Look up on Google Scholar
| | Download: |
 (1.3MB) |
Abstract
We propose an integrated Silicon-on-Insulator biosensor, fabricated with Deep UV-lithography, based on resonant microring cavities in order to detect biomolecular interaction. The shift of resonance wavelength that occurs when the surroundings of a cavity is changed, can be used for sensing. An SOI microring resonator with a radius of 5 micron is capable of detecting bulk refractive index changes of 10-4. We use the avidin/biotin high affinity couple to demonstrate good repeatability and the detection of avidin concentrations down to 50 ng/ml. Further miniaturization allows for detection of extremely low analyte concentrations while lining up the microrings in arrays allows for multiparameter analyses.
Related Research Topics
Related Projects
|
|
