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Optical label-free biosensors based on ring resonators

Research Area: Lab-on-a-chip label-free biosensors

Main Researcher: Peter Bienstman

We use nanophotonic devices fabricated in silicon to create biosensors for proteins and DNA, for a variety of applications in diagnostics, drug discovery and food safety. These sensors can be fabricated using classical electronics mass-fabrication procedures, which makes them very cheap. Moreover, many sensors can be integrated on the same chip, such that one chip can detect many biomolecules at the same time. This is interesting for lab-on-a-chip applications, e.g. for disease detection in the developping world.

The use of optical semiconductor cavities for sensing purposes is based on a measurement of the resonance wavelength shift caused by a refractive index change when a biomolecule binds to receptor molecule fixed on the cavity’s surface. This way detection occurs without an additional labeling step. The use of semi-conducting materials for optical biosensors requires non-trivial surface chemistry, on which research is done by the UGent polymer chemistry group (Prof. E. Schacht).

We are currently investigating passive SOI microrings, fabricated with DUV lithography. Thanks to the use of high refractive index contrast materials, cavities with extreme small dimensions and sharp resonance peaks can be designed.


Other people involved:

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Si based waveguide and surface plasmon sensors Si based waveguide and surface plasmon sensors

Publications

    International Journals

  1. J.W. Hoste, P. Soetaert, P. Bienstman, Improving the detection limit of conformational analysis by utilizing a dual polarization Vernier cascade, Optics Express, 24(1), p.67-81 (2016)  Download this Publication (6.6MB).
  2. A. Subramanian, E.M.P. Ryckeboer, A. Dhakal, F. Peyskens, A. Malik, B. Kuyken, H. Zhao, S. Pathak, A. Ruocco, A. De Groote, P.C. Wuytens, D. Martens, F. Leo, W. Xie, U.D. Dave, M. Muneeb, Pol Van Dorpe, Joris Van Campenhout, W. Bogaerts, P. Bienstman, N. Le Thomas, D. Van Thourhout, Zeger Hens, G. Roelkens, R. Baets, Silicon and silicon nitride photonic circuits for spectroscopic sensing on-a-chip , Photonics Research (invited), 5(3), p.B47 (2015)  Download this Publication (1.5MB).
  3. E.M.P. Ryckeboer, J. Vierendeels, A. Lee, S. Werquin, P. Bienstman, R. Baets, Measurement of small molecule diffusion with an optofluidic silicon chip, Lab on a Chip, 13(22), p.4392 - 4399 (2013)  Download this Publication (1.8MB).
  4. S. Werquin, S. Verstuyft, P. Bienstman, Integrated interferometric approach to solve microring resonance splitting in biosensor applications, Optics Express, 21(14), p.16955-16963 (2013)  Download this Publication (636KB).
  5. C. Lerma Arce, S. Van Put, A. Goes, E. Hallynck, P. Dubruel, K. Komorowska, P. Bienstman, Reaktiongefäße als neue Plattform für Sensoren mit nanophotonischen Silizium-Ringresonatoren, BioPhotonik, 6(2), p.40-42 (2013)  Download this Publication (375KB).
  6. C. Lerma Arce, D. Witters, R. Puers, J. Lammertyn, P. Bienstman, Silicon Photonic Sensors incorporated in a Digital Microfluidic System, Analytical and Bioanalytical Chemistry, 404(10), p.2887-2894 (2012)  Download this Publication (681KB).
  7. W. Bogaerts, P. De Heyn, T. Van Vaerenbergh, K. De Vos, S. Selvaraja, T. Claes, P. Dumon, P. Bienstman, D. Van Thourhout, R. Baets, Silicon microring resonators, Lasers & Photonics Reviews, 6(1), p.47-73 (2012)  Download this Publication (1.9MB).
  8. K. De Vos, Jordi Girones Molera, T. Claes, Y. De Koninck, Stepan Popelka, Etienne Schacht, R. Baets, P. Bienstman, Multiplexed antibody detection with an array of silicon-on-insulator microring resonators, IEEE Photonics Journal, 1(4), p.225-235 (2009)  Download this Publication (697KB).
  9. K. De Vos, J. Girones, S. Popelka, E. Schacht, R. Baets, P. Bienstman, SOI optical microring resonator with poly(ethylene glycol) polymer brush for label-free biosensor applications, Biosensors and Bioelectronics, 24(8), p.2528-2533 (2009)  Download this Publication (506KB).
  10. K. De Vos, I, Bartolozzi, E, Schacht, P. Bienstman, R. Baets, Silicon-on-Insulator microring resonator for sensitive and label-free biosensing, Optics Express, 15(12), p.7610-7615 (2007)  Download this Publication (273KB).
      International Conferences

    1. E.M.P. Ryckeboer, D. Martens, H. D'heer, P. Bienstman, D. Van Thourhout, R. Baets, Optofluidic devices based on Silicon photonics, EOS World of Photonics Congress (invited), (2017).
    2. C. Lerma Arce, E. Hallynck, S. Werquin, J.W. Hoste, D. Martens, P. Bienstman, Silicon photonics biosensing: different packaging platforms and application possibilities, Photonics West (invited), United States, p.932006 (2015)  Download this Publication (558KB).
    3. A. Van Eeghem, S. Werquin, E. Vanderleyden, P. Bienstman, P. Dubruel, Functionalisation of nanophotonic silicon-on-insulator biosensor chips for real-time DNA detection, Diatech 2014, Belgium, p.34-35 (2014).
    4. J.F.I.B Hoste, S. Werquin, P. Bienstman, Dual polarisation biosensing with an SOI microring, Proceedings of the 18th Annual Symposium of the IEEE Photonics Society Benelux Chapter, Netherlands, p.113-116 (2013)  Download this Publication (329KB).
    5. P. Bienstman, S. Werquin, C. Lerma Arce, E. Hallynck, T. Claes, J.W. Hoste, D. Martens, Silicon nanophotonics on-chip sensing, Progress In Electromagnetics Research Symposium (PIERS 2013) (invited), Sweden, p.1032 (2013)  Download this Publication (19KB).
    6. C. Lerma Arce, S. Van Put, A. Goes, E. Hallynck, P. Dubruel, K. Komorowska, P. Bienstman, Reaction tubes as a platform for silicon nanophotonic ring resonator biosensors, Advanced Photonics - OSA Optics & Photonics Congress, United States, p.paper IW4A.8 (2013)  Download this Publication (400KB).
    7. P. Bienstman, S. Werquin, C. Lerma Arce, D.Witters, R. Puers, J. Lammertyn, T. Claes, E. Hallynck, J.W. Hoste, D. Martens, Nanophotonic biosensors in silicon-on-insulator, The 17th International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers 2013) (invited), Spain, p.2588-2591 (2013)  Download this Publication (1.1MB).
    8. P. Bienstman, T. Claes, C. Lerma Arce, W. Bogaerts, K. Komorowska, D. Van Thourhout, Novel Ring Resonator Based Biosensors, CLEO Europe (invited), Germany, p.jsiv1.3-sun (2011)  Download this Publication (71KB).
    9. C. Lerma Arce, K. Komorowska, D. Van Thourhout, P. Bienstman, Optical fiber probe sensor based on Silicon-on-Insulator ring resonator, Annual Symposium IEEE Photonics Benelux 2010 , Netherlands, p.133-136 (2010)  Download this Publication (184KB).
    10. K. De Vos, J. Girones, T. Claes, E. Schacht, R. Baets, P. Bienstman, High throughput label-free biosensing with silicon-on-insulator microring resonators, Europt(r)ode X , Czech Republic, (2010)  Download this Publication (108KB).
    11. G. Yurtsever, K. De Vos, T. Claes, P.P.P. Debackere, P. Bienstman, R. Baets, Photonic Biosensors in Silicon-on-Insulator , 2nd International Conference On Silicon Photonics (invited), United States, (2010)  Download this Publication (124KB).
    12. K. De Vos, P.P.P. Debackere, T. Claes, J. Girones, W.A.D. De Cort, E. Schacht, R. Baets, P. Bienstman, Label-free biosensors on silicon-on-insulator optical chips, SPIE Optics and Photonics (invited), 7397(37), United States, (2009)  Download this Publication (1.5MB).
    13. K. De Vos, P.P.P. Debackere, R. Baets, P. Bienstman, Label-free biosensors on Silicon-on-Insulator optical chips based on microring cavities and surface plasmon interferometry, ICTON 2008 (invited), 2, Greece, p.88-91 (2008)  Download this Publication (325KB).
    14. W. Bogaerts, P. Dumon, J. Brouckaert, K. De Vos, D. Taillaert, D. Van Thourhout, R. Baets, Ultra-compact optical filters in Silicon-on-Insulator and their Applications, Group IV Photonics (invited), Japan, p.WA1 (2007)  Download this Publication (1.5MB).
    15. P.P.P. Debackere, K. De Vos, S. Scheerlinck, P. Bienstman, R. Baets, Silicon-on-Insulator as a Platform for Biosensors, Frontiers research Meeting, (2007)  Download this Publication (406KB).
    16. K. De Vos, I. Bartolozzi, D. Taillaert, W. Bogaerts, P. Bienstman, R. Baets, E. Schacht, Optical biosensor based on silicon-on-insolator microring cavities for specific protein detection, Proc. of SPIE Photonics West (BiOS), 6447, United States, p.6447DK-1 (2007)  Download this Publication (366KB).
    17. P.P.P. Debackere, D. Taillaert, S. Scheerlinck, K. De Vos, P. Bienstman, R. Baets, Si based waveguide and surface plasmon sensors, Photonics West 2007: Silicon Photonics II (invited), 6477, United States, p.647719 (2007)  Download this Publication (1.7MB).
    18. K. De Vos, I. Bartolozzi, P. Bienstman, R. Baets, E. Schacht, Optical Biosensor based on Silicon-on-Insulator Microring Resonators for Specific Protein Binding Detection, LEOS Benelux Annual Symposium, Netherlands, (2006)  Download this Publication (1.3MB).
    19. K. De Vos, I. Bartolozzi, P. Dumon, S. Scheerlinck, W. Bogaerts, D. Taillaert, E. Schacht, P. Bienstman, R. Baets, Silicon-on-Insulator Microring for Label-Free Biosensing , NanoBioEurope, France, (2006)  Download this Publication (1.2MB).
        National Conferences

      1. K. De Vos, J. Girones, R. Baets, P. Bienstman, Photonics microring biosensor platform, PhD Symposium, Belgium, (2008)  Download this Publication (537KB).
      2. K. De Vos, I. Bartolozzi, P. Bienstman, R. Baets, E. Schacht, Optical Biosensor based on Silicon-on-Insulator Microring Resonators for Specific Protein Binding Detection, PhD Symposium, Belgium, (2006)  Download this Publication (537KB).

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