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Authors: K. De Vos, J. Girones Molera, T. Claes, Y. De Koninck, S. Popelka, E. Schacht, R. Baets, P. Bienstman
Title: Multiplexed antibody detection with an array of silicon-on-insulator microring resonators
Format: International Journal
Publication date: 10/2009
Journal/Conference/Book: IEEE Photonics Journal
Volume(Issue): 1(4) p.225-235
DOI: 10.1109/JPHOT.2009.2035433
Citations: 116 ( - last update: 9/6/2024)
83 (OpenCitations - last update: 3/5/2024)
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Optical cavities are considered promising devices for biosensing to satisfy the high demands of the growing proteomics market. We present a prototype sensor for multiplexed label-free monitoring of biomolecular interactions based on an array of three by four silicon-on-insulator microring resonators fabricated by standard CMOS technology. Parallel read-out was performed with an infra-red camera. We have demonstrated simultaneous detection of several model antibodies in a highly specific way. For that we integrated the optical chip with low-temperature PDMS packaging, enabling excellent compatibility with the receptor molecules. We obtain very selective biomolecular interaction by grafting a 2.5 nm poly (ethylene glycol) layer to the silicon. Using silicon-on-insulator as material platform offers high sensitivity through miniaturization and low cost mass fabrication through standard CMOS technology steps. The sensors in this interrogation method are able to detect 3.4 pg/mm2 of a protein overlayer, or a theoretical total mass of about 74 ag. For this novel lab-on-a-chip, fabrication, chemistry, readout and packaging are developed to be scalable to detect hundreds of affinity interactions within several minutes.

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