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Authors: L. Wang, J. Ren, X. Han, T. Claes, X. Jian, P. Bienstman, R. Baets, M. Zhao, G. Morthier
Title: A Label-Free Optical Biosensor Built on a Low Cost Polymer Platform
Format: International Journal
Publication date: 6/2012
Journal/Conference/Book: IEEE Photonics Journal
Volume(Issue): 4(3) p.920-930
Internal Reference: [N-1271]
Download: Download this Publication (845KB) (845KB)

Abstract

Planar integrated optical biosensors are becoming more and more important as
they facilitate label-free and real-time monitoring with high sensitivity. In this paper, the
systematic work on the development of this kind of optical biosensor built on a novel polymer
platform named PSQ-Ls will be presented. The material itself is of very low cost, and the
optical devices with high performances are fabricated through a simple UV-based soft
imprint lithography technique. Especially for ring resonator, Q value as high as 5  104 and
2:7  104 are achieved in air and water condition. These optical chips are functionalized
efficiently with protein A molecules through physical immobilization, after careful investigation
of the physicochemical and chemical properties of their surface. Both bulk sensing and
surface sensing are performed. The proposed optical biosensor exhibits good response not
only to its surrounding environment’s change but also to the small amount of targeted
molecules appearing in the buffered solution, which is human-IgG in our study.


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