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Authors: E. Lengert, M. Saveleva, A. Vsevolod, P.C. Wuytens, R. Kamyshinsky, A. Vasiliev, D. Gorin, G. Sukhorukov, A. G. Skirtach, B. Parakhonskiy
Title: Silver alginate hydrogel micro- and nano- containers for theranostics: synthesis, encapsulation, remote release and detection
Format: International Journal
Publication date: 6/2017
Journal/Conference/Book: ACS Applied Materials & Interfaces
Volume(Issue): 2017(9) p.21949-21958
DOI: 10.1021/acsami.7b08147
Citations: 62 ( - last update: 19/5/2024)
21 (OpenCitations - last update: 19/4/2024)
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We have designed multifunctional silver alginate hydrogel microcontainers referred to as loaded microcapsules
with di
erent sizes by assembling them via a template assisted approach using natural, highly porous calcium carbonate cores.
Sodium alginate was immobilized into the pores of calcium carbonate particles of di
erent sizes followed by cross-linking via
addition of silver ions, which had a dual purpose: on one hand, the were used as a cross-linking agent, albeit in the monovalent
form, while on the other hand they have led to formation of silver nanoparticles. Monovalent silver ions, an unusual cross-linking
agent, improve the sensitivity to ultrasound, lead to homogeneous distribution of silver nanoparticles. Silver nanoparticles
appeared on the shell of the alginate microcapsules in the twin-structure as determined by transmission electron microscopy.
Remote release of a payload from alginate containers by ultrasound was found to strongly depend on the particle size. The
possibility to use such particles as a platform for label-free molecule detection based on the surface enhanced Raman scattering
was demonstrated. Cytotoxicity and cell uptake studies conducted in this work have revealed that microcontainers exhibit
nonessential level of toxicity with an e
cient uptake of cells. The above-described functionalities constitute building blocks of a
theranostic system, where detection and remote release can be achieved with the same carrier.

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