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Authors: P.C. Wuytens, A. Subramanian, W. H. De Vos, A. G Skirtach, R. Baets
Title: Gold nanodome-patterned microchips for intracellular surface-enhanced Raman spectroscopy
Format: International Journal
Publication date: 12/2015
Journal/Conference/Book: Analyst
Editor/Publisher: Royal Society of Chemistry, 
Volume(Issue): 140(24) p.8080-8087
DOI: 10.1039/c5an01782c
Citations: 21 ( - last update: 14/7/2024)
17 (OpenCitations - last update: 27/6/2024)
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While top-down substrates for surface-enhanced Raman spectroscopy (SERS) offer outstanding control and reproducibility of the gold nanopatterns and their related localized surface plasmon resonance, intracellular SERS experiments heavily rely on gold
nanoparticles. These nanoparticles often result in varying and uncontrollable enhancement factors. Here we demonstrate the use of top-down gold-nanostructured microchips for intracellular sensing. We develop a tunable and reproducible fabrication scheme for these microchips. Furthermore we observe the intra-
cellular uptake of these structures, and
find no immediate influence on cell viability. Finally, we perform a proof-of-concept
intracellular SERS experiment by the label-free detection of extraneous molecules. By bringing top-down SERS substrates to the intracellular world, we set an important step towards time- dependent and quantitative intracellular SERS.

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